Posts
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Chemical synthesis of Nicotine
Nicotine is one of the more addictive stimulants/anxiolytics. It is a natural alkaloid present in tobacco. It acts as both an agonist of nAChRs (nicotinic acetylcholine receptors) and an antagonist in at least two identified subunits. It has wide pharmaceutical interest and recreational usage over the counter in products such as medicine, cigarettes, tobacco products,…
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Plant steroids Diosgenin and Ecdysterone
Diosgenin is a steroidal sapogenin derived from plants that has interesting activities and properties organically. The plant it is notably derived from is known as Dioscorea Trigonella Costus. It’s pharmaceutical interest remains quite high as it is used synthetically to obtain various sex hormones and corticosteroids via partial synthesis. Diosgenin is used medically…
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Anabolic-Androgenic Steroids and some synthetic preparations thereof
Androgens can be grouped into three core categories (4,5 testosterones, 5a-reduced testosterones, 19-nortestosterones) while also having other modifitory changes such as retro or iso streroids, carbon nor or carbon homo steroids, and other novelties with anabolic/androgenic activity. Most preferred activity of androgens in most instances medicinally would be anabolic with a strong separation of androgenic…
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Adrenaline and some synthetic analogues
Epinephrine: Beyond the most simple of stimulants such as caffeine, there exist natural and bioorganic species of compounds known as epinephrines, or the adrenal hormones. They regulate adrenaline among many other things characteristic of bodily stimulation. Epinephrine, or adrenaline, is produced at a normal or alarming rate dependent on the species in consideration. It resembles…
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Chemical Synthesis of certain SARMs
Selective Androgen Receptor Modulators are a wide variety of compounds that activate the AR (Androgen Receptor) for anabolic and androgenic functionality. They are particularly useful in medicine as an alternative to steroids with hopes of less side effects. The most widely used are in the arylpropionamide family of SARMs bearing an aromatic cyclohexane…
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A Chemical Route to Yield Methyltestosterone
The starting material here is 17a-methyl-5a-androstane-3b,17b-diol (methyl-androstanediol) which is a powder then put into a liquid mixture of IBX (2-Iodoxybenzoic acid) in 1-butyl-3-methylimidazolium bromide. The overall mixture is then heated on a hot plate for approximately 2 hours or a little more depending on transformation confidence and/or TLC monitoring. The yielded Mestanolone/solvent/reagent mixture (as…
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